関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Water | HCID 962 | — |
| 反応物 | Chlorotrimethylsilane | HCID 6397 | — |
| 反応物 | Triethylamine | HCID 8471 | — |
| 反応物 | HCID 178479278 | HCID 178479278 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | HCID 178504316 | HCID 178504316 | — |
反応手順
A solution of 1.85 ml of chlorotrimethylsilane in 10 ml of CH2Cl2 is added dropwise to a solution of 2.0 g of trans-4-hydroxycyclohexylamine hydrochloride and 4.05 ml of triethylamine in 20 ml of CH2Cl2, cooled to 0° C. After stirring for 16 hours at room temperature, the mixture is hydrolyzed with water and extracted. The organic phase is washed successively with water, a 5% solution of Na2CO3 and saturated NaCl. After drying over MgSO4 and evaporation of the solvents, 1.43 g of amine (colorless liquid) are obtained.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US05624941 |
|---|
| 出典データセット | uspto-grants-1997_04 |
|---|
| ORD ID | ord-0057d01bc02e48f187b6f212ae0adc0e |
|---|
| 出典メモ | uspto-grants-1997_04 |
|---|
