Methylamine → Methyl 3-(methylamino)but-2-enoate

HRID 553660ノート

反応式

HRID 553660 の反応式
[C:1]([O:7][CH3:8])(=[O:6])[CH2:2][C:3]([CH3:5])=O.[CH3:9][NH2:10]>CO>[CH3:8][O:7][C:1](=[O:6])[CH:2]=[C:3]([NH:10][CH3:9])[CH3:5]

参加物

4

反応物 2

HCID 6329MethylamineHCID 7757Methyl acetoacetate

生成物 1

HCID 2734182Methyl 3-(methylamino)but-2-enoate

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

To a solution of methyl acetoacetate (29.4 g, 253 mmol) in methanol (30 mL) was added methylamine (33 wt % in EtOH; 48 mL, 385 mmol) dropwise at room temperature. The reaction was stirred for 1 hour, and then concentrated and dried to give the title compound as a white crystalline solid.

後処理

  1. concentrationconcentrated
  2. customdried

出典と根拠

ORDレコード
ord-c5a35a4b1c7944b1a0650f2da778ae9e
出典データセット
uspto-grants-2011_11
特許番号
US08048902B2

反応ノート

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