Piperidine → [Phenoxy(1-piperidinyl)methylene]cyanamide

HRID 55370

反応式

HRID 55370 の反応式
C1C=CC(O[C:8]([O:12][C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)=[N:9][C:10]#[N:11])=CC=1.[NH:19]1[CH2:24][CH2:23][CH2:22][CH2:21][CH2:20]1>ClCCl>[O:12]([C:8](=[N:9][C:10]#[N:11])[N:19]1[CH2:24][CH2:23][CH2:22][CH2:21][CH2:20]1)[C:13]1[CH:14]=[CH:15][CH:16]=[CH:17][CH:18]=1

参加物

4

反応物 2

HCID 8082PiperidineHCID 688090Diphenyl N-Cyanocarbonimidate

生成物 1

HCID 21460903[Phenoxy(1-piperidinyl)methylene]cyanamide収率 81.3%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

a)To a stirred solution of 6 g of diphenyl cyanocarbonimidate in 50 ml of dichloromethane at room temperature were added portionwise 2.1 g of piperidine. Stirring was continued for 30 minutes at room temperature. The reaction mixture was evaporated and the residue was crystallized from 2,2'-oxybispropane. The crystals were filtered off and dried, yielding 4.6 g (80.7%) of [phenoxy(1-piperidinyl)methylene]cyanamide; mp. 85.7° C. (interm. 32).

後処理

  1. customThe reaction mixture was evaporated
  2. customthe residue was crystallized from 2,2'-oxybispropane
  3. filtrationThe crystals were filtered off
  4. customdried

出典と根拠

ORDレコード
ord-6951041785de4eb2a2b0c68d00948d9b
出典データセット
uspto-grants-1997_04
特許番号
US05624952

関連ノート

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