o-Fluoroacetophenone → (1S)-1-(2-Fluorophenyl)ethan-1-ol

反応式

[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8](=[O:10])[CH3:9].B1(C)OC(C2C=CC=CC=2)(C2C=CC=CC=2)[C@@H]2N1CCC2>>[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C@@H:8]([OH:10])[CH3:9]

参加物

反応物 2

HCID 96744o-Fluoroacetophenone

HCID 9838490(R)-2-Methyl-CBS-oxazaborolidine

生成物 1

HCID 7023576(1S)-1-(2-Fluorophenyl)ethan-1-ol

実験手順

(S)-1-(2-Fluoro-phenyl)-ethanol was prepared according to the procedure described in Example 35, Step 1 using 2′-fluoroacetophenone and (R)-(+)-2-methyl-CBS-oxazaborolidine.

出典と根拠

ORDレコード: ord-9cbd29eeb76e4f53b20d0ecd8592f9e7
出典データセット: uspto-grants-2011_11
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US08048902B2

反応ノート

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