Benzoic acid, 3,5-dibromo- → 1-(3,5-Dibromophenyl)ethanone

HRID 553743

反応式

HRID 553743 の反応式
[Br:1][C:2]1[CH:3]=[C:4]([CH:8]=[C:9]([Br:11])[CH:10]=1)[C:5]([OH:7])=O.[CH3:12][Li]>CCOCC>[Br:11][C:9]1[CH:8]=[C:4]([C:5](=[O:7])[CH3:12])[CH:3]=[C:2]([Br:1])[CH:10]=1

参加物

4

反応物 2

HCID 12063Benzoic acid, 3,5-dibromo-HCID 178418348HCID 178418348、化合物

生成物 1

HCID 6218251-(3,5-Dibromophenyl)ethanone

試薬・触媒・溶媒 1

HCID 3283Diethyl Ether溶媒

実験手順

To a solution of 3,5-dibromobenzoic acid (2.5 g, 8.9 mmol) in Et2O (30 mL) at 0° C. was added methyl lithium (1.6M in diethyl ether; 12.3 mL, 19.6 mmol) was added dropwise. The reaction was warmed to room temperature and stirred for 2 hours. Acidic work-up, followed by silica gel chromatography, gave 1-(3,5-dibromo-phenyl)-ethanone.

後処理

  1. additionwas added dropwise

出典と根拠

ORDレコード
ord-8bd557ae417f45ce91de4786a539d9ca
出典データセット
uspto-grants-2011_11
特許番号
US08048902B2

関連ノート

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