Triethyl phosphite → diethyl[(6S*,9aR*)-6-(3-fluorophenyl)-4-oxooctahydroquinolizin-3-yl]phosphonate

HRID 553907ノート

反応式

HRID 553907 の反応式
[F:1][C:2]1[CH:3]=[C:4]([C@H:8]2[CH2:17][CH2:16][CH2:15][C@@H:14]3[N:9]2[C:10](=[O:19])[CH:11](I)[CH2:12][CH2:13]3)[CH:5]=[CH:6][CH:7]=1.[P:20]([O:27]CC)([O:24][CH2:25][CH3:26])[O:21][CH2:22][CH3:23]>>[F:1][C:2]1[CH:3]=[C:4]([C@@H:8]2[CH2:17][CH2:16][CH2:15][C@H:14]3[N:9]2[C:10](=[O:19])[CH:11]([P:20](=[O:27])([O:24][CH2:25][CH3:26])[O:21][CH2:22][CH3:23])[CH2:12][CH2:13]3)[CH:5]=[CH:6][CH:7]=1

参加物

3

反応物 2

HCID 31215Triethyl phosphiteHCID 69075941(6R*,9aS*)-6-(3-fluorophenyl)-3-iodooctahydroquinolizin-4-one

生成物 1

HCID 86612701diethyl[(6S*,9aR*)-6-(3-fluorophenyl)-4-oxooctahydroquinolizin-3-yl]phosphonate

反応条件

温度
120 °C

実験手順

A mixture of (6R*,9aS*)-6-(3-fluorophenyl)-3-iodooctahydroquinolizin-4-one (597 mg) with triethyl phosphite (6 mL) was stirred at 120° C. for five hours. The reaction solution was left to cool to room temperature and then concentrated under reduced pressure to obtain 670 mg of the title compound. The property value of the compound is as follows.

後処理

  1. waitThe reaction solution was left
  2. temperatureto cool to room temperature
  3. concentrationconcentrated under reduced pressure

出典と根拠

ORDレコード
ord-7f1632ed833e41e788419ba545947c6a
出典データセット
uspto-grants-2011_11
特許番号
US08048878B2

反応ノート

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