(4R,9aS)-4-(3,4,5-trifluorophenyl)-3,4,7,9a-tetrahydro-1H-pyrido[2,1-c][1,4]oxazin-6-one → (4R,9aS)-4-(3,4,5-Trifluorophenyl)hexahydropyrido[2,1-c][1,4]oxazin-6(1H)-one

HRID 553959ノート

反応式

HRID 553959 の反応式
[F:1][C:2]1[CH:3]=[C:4]([C@@H:10]2[CH2:15][O:14][CH2:13][C@@H:12]3[CH:16]=[CH:17][CH2:18][C:19](=[O:20])[N:11]23)[CH:5]=[C:6]([F:9])[C:7]=1[F:8].[H][H]>CO.[Pt]=O>[F:1][C:2]1[CH:3]=[C:4]([C@@H:10]2[CH2:15][O:14][CH2:13][C@@H:12]3[CH2:16][CH2:17][CH2:18][C:19](=[O:20])[N:11]23)[CH:5]=[C:6]([F:9])[C:7]=1[F:8]

参加物

5

反応物 2

HCID 67464206(4R,9aS)-4-(3,4,5-trifluorophenyl)-3,4,7,9a-tetrahydro-1H-pyrido[2,1-c][1,4]oxazin-6-oneHCID 178418361HCID 178418361、化合物

生成物 1

HCID 44124045(4R,9aS)-4-(3,4,5-Trifluorophenyl)hexahydropyrido[2,1-c][1,4]oxazin-6(1H)-one収率 100.1%

試薬・触媒・溶媒 2

HCID 82844Platinum oxide (PtO)触媒HCID 887Methanol溶媒

実験手順

Platinum oxide (20.1 mg) was added to a solution of (4R,9aS)-4-(3,4,5-trifluorophenyl)-3,4,7,9a-tetrahydro-1H-pyrido[2,1-c][1,4]oxazin-6-one (250 mg) in methanol (6 mL), and the reaction solution was stirred in a hydrogen atmosphere at room temperature for two hours. The reaction solution was filtered through celite, and the filtrate was concentrated under reduced pressure to obtain 252 mg of the title compound. The property value of the compound is as follows.

後処理

  1. filtrationThe reaction solution was filtered through celite
  2. concentrationthe filtrate was concentrated under reduced pressure

出典と根拠

ORDレコード
ord-f59087ee1c8a48f3b6475732131d0718
出典データセット
uspto-grants-2011_11
特許番号
US08048878B2

反応ノート

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