Water → 2,3-Dichloro-4-fluorobenzoic acid

HRID 554103ノート

反応式

HRID 554103 の反応式
[Cl:1][C:2]1[C:7]([Cl:8])=[C:6]([CH3:9])[CH:5]=[CH:4][C:3]=1[F:10].[Cr](O[Cr]([O-])(=O)=O)([O-])(=O)=[O:12].[K+].[K+].S(=O)(=O)(O)O.[OH2:27]>C(O)(=O)C>[Cl:8][C:7]1[C:2]([Cl:1])=[C:3]([F:10])[CH:4]=[CH:5][C:6]=1[C:9]([OH:12])=[O:27]

参加物

6

反応物 4

HCID 962WaterHCID 1118Sulfuric AcidHCID 24502Potassium DichromateHCID 67460080HCID 67460080、化合物

生成物 1

HCID 103307052,3-Dichloro-4-fluorobenzoic acid

試薬・触媒・溶媒 1

HCID 176Acetic Acid溶媒

反応条件

温度
100 °C

実験手順

2,3-dichloro-1-fluoro-4-methylbenzene (0.090 g, 0.5 mmol) was added to a stirred mixture of potassium dichromate (0.284 g, 1 mmol) in acetic acid (1 ml). 97% Sulphuric acid (0.5 ml) was then added slowly to the mixture which was subsequently heated at 100° C. for 2 hrs. After cooling to room temperature, water and ice were added and the green solid thus obtained was filtered off and washed with cold water to afford 2,3-dichloro-4-fluorobenzoic acid (0.056 g, 0.27 mmol) as a white solid.

後処理

  1. temperatureAfter cooling to room temperature
  2. customthe green solid thus obtained
  3. filtrationwas filtered off
  4. washwashed with cold water

出典と根拠

ORDレコード
ord-27f77b98261346b9a8bff941cb800a30
出典データセット
uspto-grants-2011_11
特許番号
US08048907B2

反応ノート

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