4-Fluoro-2-methylbenzenesulfonyl chloride → 1-[(4-Fluoro-2-methylphenyl)sulfonyl]-5-phenyl-1H-pyrrole-3-carbaldehyde
反応式
FC1C=CC(S(Cl)(=O)=O)=C(C)C=1.[F:13][C:14]1[CH:19]=[CH:18][C:17]([S:20]([N:23]2[C:27]([C:28]3[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=3)=[CH:26][C:25]([C:34](OCC)=[O:35])=[CH:24]2)(=[O:22])=[O:21])=[C:16]([CH3:39])[CH:15]=1>>[F:13][C:14]1[CH:19]=[CH:18][C:17]([S:20]([N:23]2[C:27]([C:28]3[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=3)=[CH:26][C:25]([CH:34]=[O:35])=[CH:24]2)(=[O:21])=[O:22])=[C:16]([CH3:39])[CH:15]=1参加物
3
実験手順
Using 4-fluoro-2-methylbenzenesulfonyl chloride instead of tosyl chloride, a procedure as in Reference Example 4 was performed to synthesize ethyl 1-[(4-fluoro-2-methylphenyl)sulfonyl]-5-phenyl-1H-pyrrole-3-carboxylate, and procedures as in Reference Examples 5 and 6 were sequentially performed to give the title compound as a pale-yellow oil.
出典と根拠
- ORDレコード
- ord-89edddae1ea64efb9d5f3c9ebc39dcdf
- 出典データセット
- uspto-grants-2011_11