Bromine → 2-Bromo-1-(2-fluorophenyl)propan-1-one
反応式
[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8](=[O:11])[CH2:9][CH3:10].[Br:12]Br>C(O)(=O)C>[Br:12][CH:9]([CH3:10])[C:8]([C:3]1[CH:4]=[CH:5][CH:6]=[CH:7][C:2]=1[F:1])=[O:11]参加物
4
実験手順
To a solution of 2′-fluoropropiophenone (25.0 g) in acetic acid (250 mL) was slowly added bromine (8.4 mL). The mixture was stirred at room temperature for 3 hr, and concentrated under reduced pressure. To the residue was added water (200 mL), and the mixture was extracted with diisopropyl ether. The extract was washed with saturated aqueous sodium hydrogencarbonate solution, water and saturated brine, dried over anhydrous magnesium sulfate, and filtrated. The filtrate was concentrated under reduced pressure to give the title compound as a yellow oil (yield 36.8 g, 97%).
後処理
- concentrationconcentrated under reduced pressure
- additionTo the residue was added water (200 mL)
- extractionthe mixture was extracted with diisopropyl ether
- washThe extract was washed with saturated aqueous sodium hydrogencarbonate solution, water and saturated brine
- dry with materialdried over anhydrous magnesium sulfate
- filtrationfiltrated
- concentrationThe filtrate was concentrated under reduced pressure
出典と根拠
- ORDレコード
- ord-056bdc7086cd4304bbd10c8510791b87
- 出典データセット
- uspto-grants-2011_11
- 特許番号
- US08048909B2
反応ノート
読み込み中…