Tosylmethyl isocyanide → HCID 66924650、化合物

反応式

C1(C)C=CC(S([CH2:10][N+:11]#[C-:12])(=O)=O)=CC=1.[CH3:14][CH:15]([CH3:22])/[CH:16]=[CH:17]/[C:18]([O:20][CH3:21])=[O:19].CC(C)([O-])C.[K+]>>[CH:15]([C:16]1[C:17]([C:18]([O:20][CH3:21])=[O:19])=[CH:10][NH:11][CH:12]=1)([CH3:22])[CH3:14]

参加物

反応物 3

HCID 161915Tosylmethyl isocyanide

HCID 5362843Methyl (2E)-4-methyl-2-pentenoate

HCID 23665647Potassium tert-butoxide

生成物 1

HCID 66924650HCID 66924650、化合物収率 54%

実験手順

Using p-toluenesulfonylmethyl isocyanide (7.6 g), methyl (2E)-4-methylpent-2-enoate (5.0 g) and potassium tert-butoxide (5.25 g), a procedure as in Reference Example 39 was performed to give the title compound as a pale-yellow oil (yield 3.5 g, 54%).

出典と根拠

ORDレコード: ord-28f0ea42c8d94945afa447292ea7a082
出典データセット: uspto-grants-2011_11
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US08048909B2

反応ノート

読み込み中…