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Sodium hydride → Methyl 2-[(4-formyl-2-phenyl-1H-pyrrol-1-yl)sulfonyl]benzoate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Sodium hydride | HCID 24758 | — |
| 反応物 | 15-Crown-5 | HCID 36336 | — |
| 反応物 | Benzoic acid, 2-(chlorosulfonyl)-, methyl ester | HCID 117830 | — |
| 反応物 | 5-Phenyl-1H-pyrrole-3-carboxaldehyde | HCID 11052090 | — |
| 生成物 | Methyl 2-[(4-formyl-2-phenyl-1H-pyrrol-1-yl)sulfonyl]benzoate | HCID 86620753 | 60% |
反応手順
Using 5-phenyl-1H-pyrrole-3-carbaldehyde (513 mg), sodium hydride (60% in oil, 216 mg), 15-crown-5 (990 mg) and methyl 2-(chlorosulfonyl)benzoate (1.06 g), a procedure as in Reference Example 219 was performed to give the title compound as a pale-yellow oil (yield 664 mg, 60%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08048909B2 |
| 出典データセット | uspto-grants-2011_11 |
| ORD ID | ord-f8a88398dbfd49268796cd1c27a7937c |
| 出典メモ | uspto-grants-2011_11 |