化工社化工社 化学情報印刷レポート · 研究参考用
Sodium hydride → Methyl 3-[(4-formyl-2-phenyl-1H-pyrrol-1-yl)sulfonyl]benzoate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Sodium hydride | HCID 24758 | — |
| 反応物 | 15-Crown-5 | HCID 36336 | — |
| 反応物 | Benzoic acid, 3-(chlorosulfonyl)-, methyl ester | HCID 113339 | — |
| 反応物 | 5-Phenyl-1H-pyrrole-3-carboxaldehyde | HCID 11052090 | — |
| 生成物 | Methyl 3-[(4-formyl-2-phenyl-1H-pyrrol-1-yl)sulfonyl]benzoate | HCID 86620754 | 69% |
反応手順
Using 5-phenyl-1H-pyrrole-3-carbaldehyde (1.32 g), sodium hydride (60% in oil, 444 mg), 15-crown-5 (2.04 g) and methyl 3-(chlorosulfonyl)benzoate (2.17 g), a procedure as in Reference Example 219 was performed to give the title compound as a pale-yellow oil (yield 1.96 g, 69%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08048909B2 |
| 出典データセット | uspto-grants-2011_11 |
| ORD ID | ord-61c2192d8a1a4e19a88fc7d0c6e0b23a |
| 出典メモ | uspto-grants-2011_11 |