Ethylamine → [2-Chloro-5-(2-ethylaminomethyl-4-trifluoromethyl-phenyl)-pyridin-3-yl]-acetic acid ethyl ester

HRID 554611ノート

反応式

HRID 554611 の反応式
[CH2:1]([O:3][C:4](=[O:25])[CH2:5][C:6]1[C:7]([Cl:24])=[N:8][CH:9]=[C:10]([C:12]2[CH:17]=[CH:16][C:15]([C:18]([F:21])([F:20])[F:19])=[CH:14][C:13]=2[CH:22]=O)[CH:11]=1)[CH3:2].[CH2:26]([NH2:28])[CH3:27]>>[CH2:1]([O:3][C:4](=[O:25])[CH2:5][C:6]1[C:7]([Cl:24])=[N:8][CH:9]=[C:10]([C:12]2[CH:17]=[CH:16][C:15]([C:18]([F:19])([F:21])[F:20])=[CH:14][C:13]=2[CH2:22][NH:28][CH2:26][CH3:27])[CH:11]=1)[CH3:2]

参加物

3

反応物 2

HCID 6341EthylamineHCID 86640533[2-Chloro-5-(2-formyl-4-trifluoromethyl-phenyl)-pyridin-3-yl]-acetic acid ethyl ester

生成物 1

HCID 86640535[2-Chloro-5-(2-ethylaminomethyl-4-trifluoromethyl-phenyl)-pyridin-3-yl]-acetic acid ethyl ester

実験手順

[2-Chloro-5-(2-formyl-4-trifluoromethyl-phenyl)-pyridin-3-yl]-acetic acid ethyl ester and ethylamine (2M in THF) were reacted as described in Example 3, Step 3 to provide [2-chloro-5-(2-ethylaminomethyl-4-trifluoromethyl-phenyl)-pyridin-3-yl]-acetic acid ethyl ester.

出典と根拠

ORDレコード
ord-302a785e85bd484596942fbd90841d7d
出典データセット
uspto-grants-2011_11
特許番号
US08049015B2

反応ノート

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