Dichloromethane → Ethyl 5-bromo-6-methoxy-3-pyridineacetate
反応式
[Br:1][C:2]1[CH:3]=[C:4]([CH2:10][C:11]#N)[CH:5]=[N:6][C:7]=1[O:8][CH3:9].[C:13](Cl)(=[O:15])[CH3:14].C(Cl)Cl.C([O-])(O)=[O:21].[Na+]>CCO>[CH2:13]([O:15][C:11](=[O:21])[CH2:10][C:4]1[CH:5]=[N:6][C:7]([O:8][CH3:9])=[C:2]([Br:1])[CH:3]=1)[CH3:14]参加物
6
反応条件
- 温度
- 50 °C
実験手順
To (5-bromo-6-methoxy-pyridin-3-yl)-acetonitrile (1.139 g, 5.02 mmol) in EtOH (11 ml) was added acetyl chloride (3.6 mL, 50.54 mmol), and the reaction was stirred at 50° C. for 24 hours, and at room temperature for 2 days. The reaction was worked up with CH2Cl2 and saturated aqueous NaHCO3, and then reacidified and extracted with CH2Cl2. The combined organic layers were dried, filtered, and concentrated to give (5-bromo-6-methoxy-pyridin-3-yl)-acetic acid ethyl ester.
後処理
- waitat room temperature for 2 days
- extractionextracted with CH2Cl2
- customThe combined organic layers were dried
- filtrationfiltered
- concentrationconcentrated
出典と根拠
- ORDレコード
- ord-eb442a421b1f46e3bd94fe6b1a2559e9
- 出典データセット
- uspto-grants-2011_11
- 特許番号
- US08049015B2
反応ノート
読み込み中…