1H-Pyrrolo(2,3-b)pyridine → methyl 2-(1H-pyrrolo[2,3-b]pyridin-1-yl)acetate

関与物質

反応手順

A procedure similar to that described in Preparation 12 was repeated, except that 1.90 g of sodium hydride (as a 55% by weight dispersion in mineral oil), 4.95 g of 7-azaindol, 100 ml of dimethylformamide and 4.2 ml of methyl bromoacetate were used, to give 7.70 g of the title compound having Rf=0.33 (on silica gel thin layer chromatography using a 2:1 by volume mixture of hexane and ethyl acetate as the developing solvent).

情報源と証拠