Glycine tert-butyl ester hydrochloride → 3-{[(2r)-2-({[6-(5-Chloro-2-methoxybenzyl)-3,7-dioxo-1,4-diazepan-1-yl]carbonyl}amino)butanoyl]amino}benzoic acid

HRID 554799

反応式

HRID 554799 の反応式
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([O:35][CH3:36])=[C:6]([CH:34]=1)[CH2:7][CH:8]1[C:14](=[O:15])[N:13]([C:16]([NH:18][CH:19]([CH2:31][CH3:32])[C:20]([NH:22]CC(OC(C)(C)C)=O)=[O:21])=[O:17])[CH2:12][C:11](=[O:33])[NH:10][CH2:9]1.Cl.C(OC(=O)CN)(C)(C)C.N[C:48]1[CH:49]=[C:50]([CH:58]=[CH:59][CH:60]=1)[C:51]([O:53]C(C)(C)C)=[O:52]>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([O:35][CH3:36])=[C:6]([CH:34]=1)[CH2:7][CH:8]1[C:14](=[O:15])[N:13]([C:16]([NH:18][C@H:19]([CH2:31][CH3:32])[C:20]([NH:22][C:48]2[CH:49]=[C:50]([CH:58]=[CH:59][CH:60]=2)[C:51]([OH:53])=[O:52])=[O:21])=[O:17])[CH2:12][C:11](=[O:33])[NH:10][CH2:9]1

参加物

4

反応物 3

HCID 2725036Glycine tert-butyl ester hydrochlorideHCID 2737408tert-Butyl-3-aminobenzoateHCID 76588771Tert-butyl {[2-({[6-(5-chloro-2-methoxybenzyl)-3,7-dioxo-1,4-diazepan-1-yl]carbonyl}amino)butanoyl]amino}acetate

生成物 1

HCID 576711613-{[(2r)-2-({[6-(5-Chloro-2-methoxybenzyl)-3,7-dioxo-1,4-diazepan-1-yl]carbonyl}amino)butanoyl]amino}benzoic acid

実験手順

Instead of the starting material compound of Example 220, that is, the glycine tert-butyl ester hydrochloride, tert-butyl 3-aminobenzoate was used for the similar procedure as in Example 220 and Example 245 to obtain the title compound.

出典と根拠

ORDレコード
ord-3847189dd9fc404cbc020cb55d2510a2
出典データセット
uspto-grants-2011_11
特許番号
US08049006B2

関連ノート

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