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Water → 2,4,6-Tris(bromomethyl)nitrobenzene
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Water | HCID 962 | — |
| 反応物 | 1,3,5-Tris(bromomethyl)benzene | HCID 530258 | — |
| 反応物 | Nitronium tetrafluoroborate | HCID 11073463 | — |
| 溶媒 | Acetonitrile | HCID 6342 | — |
| 生成物 | 2,4,6-Tris(bromomethyl)nitrobenzene | HCID 14959170 | 86.4% |
反応手順
To a solution of 5 g (0.014 mole) of the tribromide 8 in 100 ml of CH3CN was added, at room temperature and under argon atmosphere, in a dropwise fashion 3.72 g (0.028 mole) of nitronium tetrafluoroborate in 200 ml of CH3CN. The solution was then stirred for 20 minutes longer, poured into water and the mixture extracted with CH2Cl2. The CH2Cl2 extracts were washed with 10% NaHCO3, dried (Na2SO4) and solvents removed to afford 4.86 g (86%) of the desired nitro compound 27: NMR (CDCl3) 4.5 (s,6,--CH2Br), 7.55 (s,--C6H2).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05245038 |
| 出典データセット | uspto-grants-1993_09 |
| ORD ID | ord-728658d230cb49b7815fa4f092792817 |
| 出典メモ | uspto-grants-1993_09 |