HCID 178424903、化合物 → HCID 178465153、化合物

HRID 555227ノート

反応式

HRID 555227 の反応式
CC1C(C)=C(C(C2N=CNC=2)C)C=CC=1.[CH3:16][CH2:17][NH:18][C:19]([C@H:21]1[N:25]([C:26]([C@@H:28]([NH:36][C:37]([C@@H:39]([NH:44][C:45]([C@H:47]([NH:52][C:53]([C@@H:55]([NH:64][C:65]([C@@H:67]([NH:70][C:71]([C@@H:73]([NH:84][C:85]([C@@H:87]([NH:94][C:95]([C@H:97]2[NH:102][C:100](=[O:101])[CH2:99][CH2:98]2)=[O:96])[CH2:88][C:89]2[N:93]=[CH:92][NH:91][CH:90]=2)=[O:86])[CH2:74][C:75]2[C:79]3[CH:80]=[CH:81][CH:82]=[CH:83][C:78]=3[NH:77][CH:76]=2)=[O:72])[CH2:68][OH:69])=[O:66])[CH2:56][C:57]2[CH:58]=[CH:59][C:60]([OH:63])=[CH:61][CH:62]=2)=[O:54])[CH2:48][CH:49]([CH3:51])[CH3:50])=[O:46])[CH2:40][CH:41]([CH3:43])[CH3:42])=[O:38])[CH2:29][CH2:30][CH2:31][NH:32][C:33]([NH2:35])=[NH:34])=[O:27])[CH2:24][CH2:23][CH2:22]1)=[O:20].CC(O)=O>O>[CH3:16][CH2:17][NH:18][C:19]([C@H:21]1[N:25]([C:26]([C@@H:28]([NH:36][C:37]([C@@H:39]([NH:44][C:45]([C@H:47]([NH:52][C:53]([C@@H:55]([NH:64][C:65]([C@@H:67]([NH:70][C:71]([C@@H:73]([NH:84][C:85]([C@@H:87]([NH:94][C:95]([C@H:97]2[NH:102][C:100](=[O:101])[CH2:99][CH2:98]2)=[O:96])[CH2:88][C:89]2[N:93]=[CH:92][NH:91][CH:90]=2)=[O:86])[CH2:74][C:75]2[C:79]3[CH:80]=[CH:81][CH:82]=[CH:83][C:78]=3[NH:77][CH:76]=2)=[O:72])[CH2:68][OH:69])=[O:66])[CH2:56][C:57]2[CH:62]=[CH:61][C:60]([OH:63])=[CH:59][CH:58]=2)=[O:54])[CH2:48][CH:49]([CH3:51])[CH3:50])=[O:46])[CH2:40][CH:41]([CH3:43])[CH3:42])=[O:38])[CH2:29][CH2:30][CH2:31][NH:32][C:33]([NH2:35])=[NH:34])=[O:27])[CH2:24][CH2:23][CH2:22]1)=[O:20]

参加物

4

反応物 2

HCID 178424903HCID 178424903、化合物HCID 178476396HCID 178476396、化合物

生成物 1

HCID 178465153HCID 178465153、化合物

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

Beagle dogs (10-15 Kg) were sedated with medetomidine (80 μg/kg) and an endoscope was inserted via the mouth, oesophagus and stomach into the duodenum. The test solutions (10 ml), comprising leuprolide acetate (Mallinckrodt Inc, St. Louis, Mo.) with or without enhancer reconstituted in deionised water were administered intraduodenally via the endoscope. Following removal of the endoscope, sedation was reversed using atipamezole (400 μg/kg). The parenteral reference solutions comprising 1 mg Leuprolide reconstituted in 0.5 ml sterile water were administered intravenously and subcutaneously respectively.

後処理

  1. customremoval of the endoscope, sedation

出典と根拠

ORDレコード
ord-074707ea44794283a5014b6ce0496f18
出典データセット
uspto-grants-2011_11
特許番号
US08053429B2

反応ノート

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