(Oxiran-2-yl)methyl 3-nitrobenzene-1-sulfonate → (+/-)-1-Oxiranylmethyl-4-(3-phenyl-propyl)-piperazine

HRID 555308

反応式

HRID 555308 の反応式
[C:1]1([CH2:7][CH2:8][CH2:9][N:10]2[CH2:15][CH2:14][NH:13][CH2:12][CH2:11]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[O:16]1[CH2:18][CH:17]1[CH2:19]OS(C1C=CC=C([N+]([O-])=O)C=1)(=O)=O>>[O:16]1[CH2:18][CH:17]1[CH2:19][N:13]1[CH2:12][CH2:11][N:10]([CH2:9][CH2:8][CH2:7][C:1]2[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=2)[CH2:15][CH2:14]1

参加物

3

反応物 2

HCID 286836(Oxiran-2-yl)methyl 3-nitrobenzene-1-sulfonateHCID 7965341-(3-Phenylpropyl)piperazine

生成物 1

HCID 17810519(+/-)-1-Oxiranylmethyl-4-(3-phenyl-propyl)-piperazine収率 80%

実験手順

The same method as employed in the preparation of Intermediate 1 but starting from 1-(3-phenylpropyl)-piperazine and 3-nitro-benzenesulfonic acid oxiranylmethyl ester gives after Biotage chromatography the title compound as a yellow oil in a 80% yield.

出典と根拠

ORDレコード
ord-a7606830c6ef40fa8c593f3e47f355cc
出典データセット
uspto-grants-2011_11
特許番号
US08053436B1

関連ノート

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