(Oxiran-2-yl)methyl 3-nitrobenzene-1-sulfonate → (+/-)-1-(Cyclohexylmethyl)-4-(oxiran-2-ylmethyl)piperazine
反応式
[CH:1]1([CH2:7][N:8]2[CH2:13][CH2:12][NH:11][CH2:10][CH2:9]2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[O:14]1[CH2:16][CH:15]1[CH2:17]OS(C1C=CC=C([N+]([O-])=O)C=1)(=O)=O>>[CH:1]1([CH2:7][N:8]2[CH2:9][CH2:10][N:11]([CH2:17][CH:15]3[CH2:16][O:14]3)[CH2:12][CH2:13]2)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]1参加物
3
実験手順
The same method as employed in the preparation of Intermediate 1 but starting from 1-cyclohexylmethyl piperazine and (±)-3-nitro-benzenesulfonic acid oxiranylmethyl ester gives after flash chromatography the title compound as a yellow oil in a 92% yield.
出典と根拠
- ORDレコード
- ord-2b93a9fd214047b3ae7e3a165f7700a8
- 出典データセット
- uspto-grants-2011_11
- 特許番号
- US08053436B1
反応ノート
読み込み中…