関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Thiocarbonyl diimidazole | HCID 11412697 | — |
| 反応物 | 6-(2-tert-Butylphenoxy)-N2-methylpyridine-2,5-diamine | HCID 59857348 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | 6-(2-tert-butylphenoxy)-5-isothiocyanato-N-methylpyridin-2-amine | HCID 59857446 | — |
反応手順
A solution of 136d (16.28 mg, 0.0600 mmol) in anhydrous DCM (1.0 mL) was added dropwise to a cold solution of thiocarbonyl diimidazole (21.39 mg, 0.1200 mmol) in anhydrous DCM (0.50 mL). The reaction was stirred at 0° C. for 1 h and then warmed to rt with stirring for 2 h. The mixture was concentrated down and the residue was flushed through a plug of silica gel with 10% EtOAc in hexanes. Concentration of the eluent afforded 136e.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 特許番号 | US08053450B2 |
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| 出典データセット | uspto-grants-2011_11 |
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| ORD ID | ord-3629865681d249a9b775d7348a6d1555 |
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| 出典メモ | uspto-grants-2011_11 |
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