Glycolic Acid → 2-Hydroxymethyl-3-methyl-5-phenylimidazo[5,4-b]pyridine

HRID 55543ノート

反応式

HRID 55543 の反応式
[NH2:1][C:2]1[C:3]([NH:14][CH3:15])=[N:4][C:5]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)=[CH:6][CH:7]=1.[C:16]([OH:20])(=O)[CH2:17]O>>[OH:20][CH2:16][C:17]1[N:14]([CH3:15])[C:3]2=[N:4][C:5]([C:8]3[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=3)=[CH:6][CH:7]=[C:2]2[N:1]=1

参加物

3

反応物 2

HCID 757Glycolic AcidHCID 108456893-Amino-2-methylamino-6-phenylpyridine

生成物 1

HCID 108475892-Hydroxymethyl-3-methyl-5-phenylimidazo[5,4-b]pyridine収率 15.3%

実験手順

A procedure similar to that described in Preparation 43 was repeated, except that 4.9 g of 3-amino-2-methylamino-6-phenylpyridine (prepared as described in Preparation 109) and 5.6 g of glycolic acid were used, and that the product was purified by column chromatography through silica gel, using a gradient elution method, with mixtures of ethyl acetate and ethanol in ratios ranging from 1:0 to 10:1 by volume as the eluent, to give 0.9 g of the title compound, melting at 174°-177° C.

後処理

  1. customA procedure similar to that described in Preparation 43
  2. customthat the product was purified by column chromatography through silica gel
  3. washa gradient elution method

出典と根拠

ORDレコード
ord-fb5408ab5a8a4481ba4038554b03a6da
出典データセット
uspto-grants-1997_04
特許番号
US05624935

反応ノート

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