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Piperidine → 3-((5-(hydroxymethyl)furan-2-yl) methylene)-N-acetyl-2-oxoindoline
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Piperidine | HCID 8082 | — |
| 反応物 | 5-(Hydroxymethyl)furfural | HCID 237332 | — |
| 反応物 | 1-Acetylindolin-2-one | HCID 323719 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | 3-((5-(hydroxymethyl)furan-2-yl) methylene)-N-acetyl-2-oxoindoline | HCID 66986626 | — |
反応手順
N-acetyloxindole (1 equivalent), 5-hydroxymethyl-2-furaldehyde (0.5 equivalent) and piperidine (0.2 equivalent) were dissolved in ethanol such that 1 mL of ethanol was used per 1 μmol of the total amount of the compounds, and the resulting mixture was stirred at room temperature for 12 hours. After completion of the reaction, the resulting precipitate was collected by filtration, washed with cooled ethanol several times and dried, whereby 3-((5-(hydroxymethyl)furan-2-yl) methylene)-N-acetyl-2-oxoindoline was obtained.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08053461B2 |
| 出典データセット | uspto-grants-2011_11 |
| ORD ID | ord-d681d2db206c4d6eadb06b44412df9dd |
| 出典メモ | uspto-grants-2011_11 |