Ethyl 4-(benzyloxycarbonylamino)bicyclo[2.2.2]octane-1-carboxylate → Ethyl 4-aminobicyclo[2.2.2]octane-1-carboxylate

HRID 555675

反応式

HRID 555675 の反応式
C(OC([NH:11][C:12]12[CH2:19][CH2:18][C:15]([C:20]([O:22][CH2:23][CH3:24])=[O:21])([CH2:16][CH2:17]1)[CH2:14][CH2:13]2)=O)C1C=CC=CC=1.[H][H]>C(O)C.[C].[Pd]>[NH2:11][C:12]12[CH2:17][CH2:16][C:15]([C:20]([O:22][CH2:23][CH3:24])=[O:21])([CH2:14][CH2:13]1)[CH2:18][CH2:19]2

参加物

5

反応物 2

HCID 10616503Ethyl 4-(benzyloxycarbonylamino)bicyclo[2.2.2]octane-1-carboxylateHCID 178418361HCID 178418361、化合物

生成物 1

HCID 23149693Ethyl 4-aminobicyclo[2.2.2]octane-1-carboxylate収率 100.4%

試薬・触媒・溶媒 2

HCID 178418390HCID 178418390、化合物触媒HCID 702Ethanol溶媒

実験手順

Ethyl 4-benzyloxycarbonylaminobicyclo[2.2.2]octane-1-carboxylate (40.0 g) was dissolved in ethanol (400 mL). To this solution, 10% palladium-carbon (4.00 g) was added and the mixture was stirred at room temperature for 6 hours in a stream of hydrogen. The catalyst in the reaction mixture was filtered through a Celite pad and the filtered catalyst, together with the Celite pad, was washed with ethanol. The filtrate and the washings were combined and concentrated under reduced pressure. The resulting residue was dried under reduced pressure to give ethyl 4-aminobicyclo[2.2.2]octane-1-carboxylate (23.9 g).

後処理

  1. filtrationThe catalyst in the reaction mixture was filtered through a Celite pad
  2. washthe filtered catalyst, together with the Celite pad, was washed with ethanol
  3. concentrationconcentrated under reduced pressure
  4. customThe resulting residue was dried under reduced pressure

出典と根拠

ORDレコード
ord-2b82e76f8a234554b2fedbe45a240614
出典データセット
uspto-grants-2011_11
特許番号
US08053465B2

関連ノート

読み込み中…