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Pentafluorobenzyl bromide → HCID 59383141、化合物
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Pentafluorobenzyl bromide | HCID 74484 | — |
| 反応物 | (2S,4S)-1-[[N-(4-carboxybicyclo[2,2,2]oct-1-yl)amino]acetyl]-4-fluoropyrrolidine-2-carbonitrile | HCID 57634365 | — |
| 生成物 | HCID 59383141 | HCID 59383141 | 89.7% |
反応手順
In a similar manner to Example 8, (2S,4S)-1-[[N-(4-carboxybicyclo[2.2.2]oct-1-yl)amino]acetyl]-4-fluoropyrrolidine-2-carbonitrile (30.0 mg) and 2,3,4,5,6-pentafluorobenzyl bromide (26.6 mg) were used to obtain (2S,4S)-4-fluoro-1-[[N-[4-(2,3,4,5,6-pentafluorobenzyl)oxycarbonylbicyclo[2.2.2]oct-1-yl]amino]acetyl]pyrrolidine-2-carbonitrile (41.9 mg).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08053465B2 |
| 出典データセット | uspto-grants-2011_11 |
| ORD ID | ord-8c1b1bdf78cd42f384105cb04523b0bd |
| 出典メモ | uspto-grants-2011_11 |