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Bromoacetonitrile → (4-Pyridin-2-ylmethyl-piperazin-1-yl)-acetonitrile
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Bromoacetonitrile | HCID 11534 | — |
| 反応物 | 1-[(Pyridin-2-yl)methyl]piperazine | HCID 808714 | — |
| 生成物 | (4-Pyridin-2-ylmethyl-piperazin-1-yl)-acetonitrile | HCID 60705417 | — |
反応手順
The title compound is synthesized by coupling of 1-Pyridin-2-ylmethyl-piperazine (commercially available from CHESS GmbH) and bromoacetonitrile analogously to the preparation of Intermediate 149.2 as a brown solid; ES-MS: M+=217.2: 1HNMR(DMSO-d6) 8.45 (dd, 1H), 7.75 (td, 1H), 7.40 (d, 1H), 7.25-7.20 (m, 1H), 3.70 (s, 2H), 3.60 (s, 2H), 2.50-2.35 (m, 8H).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08053457B2 |
| 出典データセット | uspto-grants-2011_11 |
| ORD ID | ord-fba3d5edf14e470fb87f1a886cb3ce80 |
| 出典メモ | uspto-grants-2011_11 |