4-Methoxycyclohexanol (cis,trans) → 4-Methoxycyclohexanone

HRID 555831

反応式

HRID 555831 の反応式
[CH3:1][O:2][CH:3]1[CH2:8][CH2:7][CH:6]([OH:9])[CH2:5][CH2:4]1.[Cr](Cl)([O-])(=O)=O.[NH+]1C=CC=CC=1>C(Cl)Cl>[CH3:1][O:2][CH:3]1[CH2:8][CH2:7][C:6](=[O:9])[CH2:5][CH2:4]1

参加物

4

反応物 2

HCID 1403324-Methoxycyclohexanol (cis,trans)HCID 178418287HCID 178418287、化合物

生成物 1

HCID 5350284-Methoxycyclohexanone

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

4-Methoxycyclohexanol (2.0 g, 15.0 mmol) was taken up in 150 mL of DCM. Pyridinium chlorochromate (5.0 g, 23.0 mmol) was added. After 60 hours, the mixture was filtered through a plug of Florisil and concentrated under reduced pressure. The residue was taken up in 50 mL of ether and filtered through a plug of silica gel. The solvent was removed under reduced pressure, affording 4-methoxycyclohexanone as a light yellow oil.

後処理

  1. filtrationthe mixture was filtered through a plug of Florisil
  2. concentrationconcentrated under reduced pressure
  3. filtrationfiltered through a plug of silica gel
  4. customThe solvent was removed under reduced pressure

出典と根拠

ORDレコード
ord-f507dd16125c411db6001cdd6e80706a
出典データセット
uspto-grants-2011_11
特許番号
US08053438B2

関連ノート

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