Potassium Carbonate → alpha-IONOL

HRID 556120

反応式

HRID 556120 の反応式
C([O-])([O-])=O.[K+].[K+].[CH3:7][C:8]1[CH:13](/[CH:14]=[CH:15]/[C:16]([CH3:18])=[O:17])[C:12]([CH3:20])([CH3:19])[CH2:11][CH2:10][CH:9]=1.[H][H]>CC(O)C>[CH3:7][C:8]1[CH:13](/[CH:14]=[CH:15]/[CH:16]([OH:17])[CH3:18])[C:12]([CH3:19])([CH3:20])[CH2:11][CH2:10][CH:9]=1

参加物

5

反応物 3

HCID 11430Potassium CarbonateHCID 5282108Alpha-IononeHCID 178418361HCID 178418361、化合物

生成物 1

HCID 5363817alpha-IONOL収率 100%

試薬・触媒・溶媒 1

HCID 3776Isopropanol溶媒

実験手順

Under a nitrogen atmosphere, 64 mg of RuCl2 [(S)-DM-BINAP][(S)-DAIPEN], 720 mg of K2CO3, 100 mL of IPA, and g of α-ionone as a racemic form were mixed. After deaeration, the obtained mixture was subjected to an asymmetric hydrogenation at 30° C. and a hydrogen pressure of 3 MPa for 21 hours. The reaction pressure was returned to the constant pressure. It was confirmed by GC that the raw material disappeared, and a post-treatment was then carried out by a conventional method, to give 20.2 g of desired optically active α-ionol (100% yield; 90% e.e.; 0% d.e.).

後処理

  1. customwas subjected to an asymmetric hydrogenation at 30° C.
  2. customThe reaction pressure
  3. customto give 20.2 g

出典と根拠

ORDレコード
ord-4dfe448f02f0478cbd6d6026d2c193fd
出典データセット
uspto-grants-2011_11
特許番号
US08053592B2

関連ノート

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