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Acetyl chloride → 4-Phenyl-2-pyridinecarbonitrile
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Acetyl chloride | HCID 6367 | — |
| 反応物 | Sodium Carbonate | HCID 10340 | — |
| 反応物 | 4-Phenylpyridine-1-oxide | HCID 70803 | — |
| 反応物 | Trimethylsilyl cyanide | HCID 82115 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | 4-Phenyl-2-pyridinecarbonitrile | HCID 87758 | — |
反応手順
To a solution of 4-phenylpyridine N-oxide (5 g) in DCM (50 mL) was added at RT trimethylsilylcyanide (11 mL), followed by acetyl chloride (3.1 mL) over 10 min. The reaction mixture was stirred overnight at RT. A solution of aq. 10% Na2CO3 was added and the mixture was extracted with EA. The combined org. phases were washed with brine, dried (Na2SO4) and evaporated off. Filtration over a plug of silica gel (Hept/EA 1/1) gave the desired compound (450 mg).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08058263B2 |
| 出典データセット | uspto-grants-2011_11 |
| ORD ID | ord-9c430b76a63140548e31507170d80bec |
| 出典メモ | uspto-grants-2011_11 |