Sodium ethoxide → 2-Chloro-4-ethoxy-9-methyl-7-phenyl-pyrido[3',2':4,5]furo[3,2-d]pyrimidine

HRID 556419ノート

反応式

HRID 556419 の反応式
[Cl:1][C:2]1[N:3]=[C:4](Cl)[C:5]2[O:10][C:9]3[N:11]=[C:12]([C:16]4[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=4)[CH:13]=[C:14]([CH3:15])[C:8]=3[C:6]=2[N:7]=1.[CH3:23][CH2:24][O-:25].[Na+]>C(O)C>[Cl:1][C:2]1[N:3]=[C:4]([O:25][CH2:24][CH3:23])[C:5]2[O:10][C:9]3[N:11]=[C:12]([C:16]4[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=4)[CH:13]=[C:14]([CH3:15])[C:8]=3[C:6]=2[N:7]=1

参加物

4

反応物 2

HCID 2723922Sodium ethoxideHCID 597550892,4-Dichloro-9-methyl-7-phenyl-pyrido[3',2':4,5]furo-[3,2-d]pyrimidine

生成物 1

HCID 231092842-Chloro-4-ethoxy-9-methyl-7-phenyl-pyrido[3',2':4,5]furo[3,2-d]pyrimidine収率 46.1%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

0.2 g (0.6 mmol) 2,4-dichloro-9-methyl-7-phenyl-pyrido[3′,2′:4,5]furo-[3,2-d]pyrimidine and 0.12 g (1.8 mmol) sodium ethylate are added by stirring into 50 ml absolute ethanol at room temperature for 24 h. Then, the precipitate is sucked off, washed with about 40 ml water and dried. Following flash chromatography, 94 mg (46%) 2-chloro-4-ethoxy-9-methyl-7-phenyl-pyrido[3′,2′:4,5]furo[3,2-d]pyrimidine is obtained.

後処理

  1. washwashed with about 40 ml water
  2. customdried

出典と根拠

ORDレコード
ord-486e218715d646f683e1c05cd518a7ab
出典データセット
uspto-grants-2011_11
特許番号
US08058285B2

反応ノート

読み込み中…