Rac-{[6-chloro-3-(3-chloro-benzyl)-2-oxo-2,3-dihydro-1h-indol-3-yl]-isopropyl-amino}-acetic acid ethyl ester → Rac-{[6-chloro-3-(3-chloro-benzyl)-2-oxo-2,3-dihydro-1h-indol-3-yl]-isopropyl-amino}-acetic acid
反応式
C([O:3][C:4](=[O:29])[CH2:5][N:6]([C:10]1([CH2:21][C:22]2[CH:27]=[CH:26][CH:25]=[C:24]([Cl:28])[CH:23]=2)[C:18]2[C:13](=[CH:14][C:15]([Cl:19])=[CH:16][CH:17]=2)[NH:12][C:11]1=[O:20])[CH:7]([CH3:9])[CH3:8])C>CO.[OH-].[K+]>[Cl:19][C:15]1[CH:14]=[C:13]2[C:18]([C:10]([N:6]([CH2:5][C:4]([OH:29])=[O:3])[CH:7]([CH3:9])[CH3:8])([CH2:21][C:22]3[CH:27]=[CH:26][CH:25]=[C:24]([Cl:28])[CH:23]=3)[C:11](=[O:20])[NH:12]2)=[CH:17][CH:16]=1参加物
4
反応物 1
生成物 1
試薬・触媒・溶媒 2
実験手順
rac-{[6-Chloro-3-(3-chloro-benzyl)-2-oxo-2,3-dihydro-1H-indol-3-yl]-isopropyl-amino}-acetic acid ethyl ester (4.5 g, 10.4 mmol) was dissolved in a mixture of MeOH and KOH aqueous solution. This mixed solution was refluxed overnight and then the solution was concentrated. The PH of water layer was adjusted to 5-6 and then the water layer was extracted with dichloromethane. The organic layer was dried, concentrated and purified by chromatography to obtain 3.2 g solid rac-{[6-Chloro-3-(3-chloro-benzyl)-2-oxo-2,3-dihydro-1H-indol-3-yl]-isopropyl-amino}-acetic acid.