2-Fluorophenylboronic acid → HCID 9856557、化合物

反応式

[NH2:1][C:2]1[C:7]([CH:8]=[O:9])=[C:6](Cl)[N:5]=[C:4]([S:11][CH3:12])[N:3]=1.[F:13][C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=1B(O)O>>[NH2:1][C:2]1[C:7]([CH:8]=[O:9])=[C:6]([C:15]2[CH:16]=[CH:17][CH:18]=[CH:19][C:14]=2[F:13])[N:5]=[C:4]([S:11][CH3:12])[N:3]=1

参加物

反応物 2

HCID 27343542-Fluorophenylboronic acid

HCID 98557864-Amino-6-chloro-2-methylsulfanylpyrimidine-5-carbaldehyde

生成物 1

HCID 9856557HCID 9856557、化合物

実験手順

Prepared as described above in Example 11 starting from 4-amino-6-chloro-2-methylsulfanyl-pyrimidine-5-carbaldehyde and 2-fluorophenylboronic acid to give the title compound 4-amino-6-(2-fluoro-phenyl)-2-methylsulfanyl-pyrimidine-5-carbaldehyde. 1H-NMR: δ 2.59 (s, 3H), 5.78 (br s, 1H), 7.11-7.32 (m, 2H), 7.42-7.58 (m, 2H), 8.65 (br s, 1H), 9.71 (s, 1H). LC MS (m/e)=264 (MH+).

後処理

customPrepared

出典と根拠

ORDレコード: ord-30f4d833c1e9438cb7b9a70eed5967d2
出典データセット: uspto-grants-2011_11
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US08058282B2

反応ノート

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