化工社化工社 化学情報印刷レポート · 研究参考用
Dimethylformamide → 1-(2-nitrophenyl)-1H-pyrrole-2-carbaldehyde
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Dimethylformamide | HCID 6228 | — |
| 反応物 | Phosphorus oxychloride | HCID 24813 | — |
| 反応物 | Sodium Acetate | HCID 517045 | — |
| 反応物 | 1-(2-Nitrophenyl)pyrrole | HCID 520611 | — |
| 溶媒 | Water | HCID 962 | — |
| 溶媒 | Carbon Tetrachloride | HCID 5943 | — |
| 生成物 | 1-(2-nitrophenyl)-1H-pyrrole-2-carbaldehyde | HCID 4715391 | 65% |
反応手順
POCl3 was added to DMF at 0-10° C. after which 50 ml of CCl4 was added at room temperature. A solution of 4.5 g (24 mmol) 1a in 50 ml of CCl4 was added slowly to the reaction mixture at about 10° C. during 1 hour. The reaction mixture was refluxed for 15 min. and a solution of 50 g of NaOAc, 3H2O in 50 ml of H2O was added and refluxing was continued for 15 min. The mixture was cooled, extracted with ether and dried over Na2SO4. 8.0 g (65%) of 2a was isolated by column chromatography using EtOAc:petroleum ether as eluent.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08058306B2 |
| 出典データセット | uspto-grants-2011_11 |
| ORD ID | ord-e51942fef4734edd9a97c030c059bd16 |
| 出典メモ | uspto-grants-2011_11 |