5-Amino-3-chloropyrazine-2-carbonitrile → 5-Amino-3-methoxypyrazine-2-carbonitrile

HRID 556881

反応式

HRID 556881 の反応式
[NH2:1][C:2]1[N:3]=[C:4](Cl)[C:5]([C:8]#[N:9])=[N:6][CH:7]=1.[CH3:11][O-:12].[Na+].CO>CO.O>[NH2:1][C:2]1[N:3]=[C:4]([O:12][CH3:11])[C:5]([C:8]#[N:9])=[N:6][CH:7]=1

参加物

5

反応物 2

HCID 210753925-Amino-3-chloropyrazine-2-carbonitrileHCID 23694274Sodium methanolate methanol

生成物 1

HCID 596133845-Amino-3-methoxypyrazine-2-carbonitrile収率 58%

試薬・触媒・溶媒 2

HCID 887Methanol溶媒HCID 962Water溶媒

反応条件

温度
80 °C

実験手順

5-Amino-3-chloropyrazine-2-carbonitrile (52 mg, 0.34 mmol) was suspended in NaOMe/MeOH (2M, 2 mL). The reaction mixture was heated at 80° C. for 30 min using microwave irradiation. After cooling, the mixture was diluted with MeOH (3 mL) and water (2 mL). The solvents were concentrated and the resulting precipitate was filtered off, washed with water (3 mL) and dried in vacuo to give the title compound as a yellow solid (33 mg, 58%).

後処理

  1. custommicrowave irradiation
  2. temperatureAfter cooling
  3. concentrationThe solvents were concentrated
  4. filtrationthe resulting precipitate was filtered off
  5. washwashed with water (3 mL)
  6. customdried in vacuo

出典と根拠

ORDレコード
ord-3225739478654ae88199617ad3e4528c
出典データセット
uspto-grants-2011_11
特許番号
US08058045B2

関連ノート

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