関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Propionyl chloride | HCID 62324 | — |
| 反応物 | 2-(Phenylamino)Benzamide | HCID 96455 | — |
| 反応物 | Sodium Bicarbonate | HCID 516892 | — |
| 溶媒 | Chloroform | HCID 6212 | — |
| 生成物 | 2-Ethyl-1-phenyl-1H-quinazolin-4-one | HCID 66991027 | — |
反応手順
2.0 g (9.42 mmol) 2-phenylamino-benzamide were dissolved in 30 ml trichloromethane the solution was cooled to 0° C., and 2.61 g (2.44 ml, 28.2 mmol) propionyl chloride was added slowly. The mixture was boiled for 90 minutes and afterwards neutralized with a saturated sodium bicarbonate solution. After evaporation the substance was crystallized from isopropanol.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US08058431B2 |
|---|
| 出典データセット | uspto-grants-2011_11 |
|---|
| ORD ID | ord-3a03597141834694b183180e548982e9 |
|---|
| 出典メモ | uspto-grants-2011_11 |
|---|
