化工社化工社 化学情報印刷レポート · 研究参考用
Lawesson's reagent → 2-Ethyl-1-phenyl-1H-quinazolin-4-thione
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Lawesson's reagent | HCID 87949 | — |
| 反応物 | 2-Ethyl-1-phenyl-1H-quinazolin-4-one | HCID 66991027 | — |
| 溶媒 | Toluene | HCID 1140 | — |
| 生成物 | 2-Ethyl-1-phenyl-1H-quinazolin-4-thione | HCID 86635529 | — |
反応手順
1.50 g (5.99 mmol) 2-ethyl-1-phenyl-1H-quinazolin-4-one and 2.42 g (5.99 mmol) Lawesson's reagent (C14H14O2P2S4, Fluka) were suspended in 40 ml toluene and boiled for 1 h. After evaporation the crude mixture was purified by column chromatography on silica gel, eluent dichloromethane/acetone 95/5.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08058431B2 |
| 出典データセット | uspto-grants-2011_11 |
| ORD ID | ord-551f6864684842a4b28a5737d7b2c144 |
| 出典メモ | uspto-grants-2011_11 |