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Sodium Iodide → 2-Iodo-1-morpholin-4-yl-ethanone
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Sodium Iodide | HCID 5238 | — |
| 反応物 | Morpholine, 4-(chloroacetyl)- | HCID 74040 | — |
| 溶媒 | Methyl Ethyl Ketone | HCID 6569 | — |
| 溶媒 | Ethyl Acetate | HCID 8857 | — |
| 生成物 | 2-Iodo-1-morpholin-4-yl-ethanone | HCID 11265309 | 86.1% |
反応手順
Dissolve 1-chloro-2-oxo-2-(morpholin-4-yl)ethane (7.0 g, 42.8 mmol) and sodium iodide (8.0 g, 53.4 mmol) in 2-butanone (150 mL) and reflux for 3 hours under nitrogen. Dilute with ethyl acetate (200 mL), filter, concentrate under reduced pressure and chromatograph on flash silica using neat ethyl acetate to obtain 9.4 g (86%) of the title compound as a yellow oil.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08058425B2 |
| 出典データセット | uspto-grants-2011_11 |
| ORD ID | ord-994137f221d641ddab06c2229a5332d0 |
| 出典メモ | uspto-grants-2011_11 |