Water → HCID 17962881、化合物

HRID 557579ノート

反応式

HRID 557579 の反応式
B(Br)(Br)Br.[C:5]([N:8]1[C:17]2[C:12](=[CH:13][C:14]([O:18]C)=[CH:15][CH:16]=2)[C:11]([C:21]2[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=2)([CH3:20])[CH2:10][C:9]1([CH3:28])[CH3:27])(=[O:7])[CH3:6].O>ClCCl>[C:5]([N:8]1[C:17]2[C:12](=[CH:13][C:14]([OH:18])=[CH:15][CH:16]=2)[C:11]([C:21]2[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=2)([CH3:20])[CH2:10][C:9]1([CH3:28])[CH3:27])(=[O:7])[CH3:6]

参加物

5

反応物 3

HCID 962WaterHCID 25134Boron tribromideHCID 17962883HCID 17962883、化合物

生成物 1

HCID 17962881HCID 17962881、化合物

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

Boron tribromide (1.30 ml) was added dropwise to a cooled (0° C.) solution of 1-acetyl-6-methoxy-4-phenyl-1,2,3,4-tetrahydro-2,2,4-trimethylquinoline (0.9 g) in dichloromethane (75 ml). After stirring for 18 h, the reaction mixture was poured into water and extracted with ethyl acetate. The organic layer was washed with water, 5% aq. NaHCO3 and water, dried (MgSO4) and concentrated in vacuo.

後処理

  1. extractionextracted with ethyl acetate
  2. washThe organic layer was washed with water, 5% aq. NaHCO3 and water
  3. dry with materialdried (MgSO4)
  4. concentrationconcentrated in vacuo

出典と根拠

ORDレコード
ord-01ea5e89875a426284cdf93c8a3d7617
出典データセット
uspto-grants-2011_11
特許番号
US08058441B2

反応ノート

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