関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | Ethyl Acetate | HCID 8857 | — |
| 反応物 | Benzoic acid, 3,5-dibromo- | HCID 12063 | — |
| 反応物 | HCID 178418348 | HCID 178418348 | — |
| 溶媒 | Diethyl Ether | HCID 3283 | — |
| 生成物 | 1-(3,5-Dibromophenyl)ethanone | HCID 621825 | — |
反応手順
To a solution of 3,5-dibromobenzoic acid (2.5 g, 8.9 mmol) in Et2O (30 mL) at 0° C. was added methyllithium (1.6M in Et2O; 12.3 mL, 19.6 mmol) dropwise. The reaction was stirred at 0° C. for 2 hours, and then worked-up with EtOAc and 10% aqueous HCl. The crude material was purified by silica gel chromatography to give the title compound.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US08058300B2 |
|---|
| 出典データセット | uspto-grants-2011_11 |
|---|
| ORD ID | ord-39c48f6d7e864b28b0186d9de9d4f0ef |
|---|
| 出典メモ | uspto-grants-2011_11 |
|---|
