化工社化工社 化学情報印刷レポート · 研究参考用
1,2-Dichloroethane → Pentafluorophenyl (1-azabicyclo[2.2.2]oct-3-yl)acetate hydrochloride
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 1,2-Dichloroethane | HCID 11 | — |
| 反応物 | Pentafluorophenol | HCID 13041 | — |
| 反応物 | 2-(Quinuclidin-3-yl)acetic acid hydrochloride | HCID 23024147 | — |
| 触媒 | Diisopropylethylamine | HCID 81531 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | Pentafluorophenyl (1-azabicyclo[2.2.2]oct-3-yl)acetate hydrochloride | HCID 86610796 | — |
反応手順
358 mg (1.94 mmol) of pentafluorophenol, 120.5 mg (0.63 mmol) of EDC and 1 drop of N,N-diisopropylethylamine are added to a solution of 100 mg (0.49 mmol) of 1-azabicyclo[2.2.2]oct-3-ylacetic acid hydrochloride in 4 ml of dichloromethane at 0° C. The mixture is stirred at room temperature for 18 h. The contents of the flask are concentrated in vacuo and dried under high vacuum. The resulting crude product is employed without further purification in the following stages.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09433614B2 |
| 出典データセット | uspto-grants-2016_09 |
| ORD ID | ord-b3b1aaa0e07f4281b55d14c723e1b6a1 |
| 出典メモ | uspto-grants-2016_09 |