Trifluoromethane → [3-(3-Chloro-5-cyano-phenoxy)-4-ethyl-2-fluoro-phenyl]-acetic acid ethyl ester

反応式

[CH:1](F)(F)F.[CH2:5]([O:7][C:8](=[O:28])[CH2:9][C:10]1[CH:15]=[CH:14][C:13]([CH3:16])=[C:12]([O:17][C:18]2[CH:23]=[C:22]([C:24]#[N:25])[CH:21]=[C:20]([Cl:26])[CH:19]=2)[C:11]=1[F:27])[CH3:6].C([Zn]CC)C>>[CH2:5]([O:7][C:8](=[O:28])[CH2:9][C:10]1[CH:15]=[CH:14][C:13]([CH2:16][CH3:1])=[C:12]([O:17][C:18]2[CH:23]=[C:22]([C:24]#[N:25])[CH:21]=[C:20]([Cl:26])[CH:19]=2)[C:11]=1[F:27])[CH3:6]

参加物

反応物 3

HCID 6373Trifluoromethane

HCID 66999330[3-(3-Chloro-5-cyano-phenoxy)-2-fluoro-4-methyl-phenyl]-acetic acid ethyl ester

HCID 178418750HCID 178418750、化合物

生成物 1

HCID 11545030[3-(3-Chloro-5-cyano-phenoxy)-4-ethyl-2-fluoro-phenyl]-acetic acid ethyl ester

実験手順

[3-(3-Chloro-5-cyano-phenoxy)-4-ethyl-2-fluoro-phenyl]-acetic acid ethyl ester (R-32) was prepared from R-23 using the procedure described for R-31 except diethylzinc was used in place of dimethylzinc.

出典と根拠

ORDレコード: ord-95dca1d90ba64da8b687351cae236ec6
出典データセット: uspto-grants-2011_11
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US08063028B2

反応ノート

読み込み中…

参加物