化工社化工社 化学情報印刷レポート · 研究参考用
Sodium Carbonate → 5-(6-Hydroxyquinolin-2-yl)thiophene-2-carbonitrile
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Sodium Carbonate | HCID 10340 | — |
| 反応物 | 2-Chloro-6-methoxyquinoline | HCID 83647 | — |
| 反応物 | 5-Cyanothiophene-2-boronic acid | HCID 4198743 | — |
| 溶媒 | 1,2-Dimethoxyethane | HCID 8071 | — |
| 生成物 | 5-(6-Hydroxyquinolin-2-yl)thiophene-2-carbonitrile | HCID 66980042 | — |
反応手順
Followed the two step synthesis shown in Scheme 1 starting with 2-chloro-6-methoxyquinoline and 5-cyanothiophen-2-ylboronic acid, with minor variations: the base used in step 1 was sodium carbonate and the solvent was DME (dimethoxyethane)/water. In step 2, after quenching w/ice water, a standard ethyl acetate extraction was preformed followed by purification by prep-TLC (PE: EA=1:1).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09433618B2 |
| 出典データセット | uspto-grants-2016_09 |
| ORD ID | ord-142f8f3882e1471e8bb723a571b8afe9 |
| 出典メモ | uspto-grants-2016_09 |