Triethylamine → Methyl 1-(6-methoxy-3-(trifluoromethyl)quinolin-2-yl)piperidine-4-carboxylate

HRID 55816

反応式

HRID 55816 の反応式
Cl[C:2]1[C:11]([C:12]([F:15])([F:14])[F:13])=[CH:10][C:9]2[C:4](=[CH:5][CH:6]=[C:7]([O:16][CH3:17])[CH:8]=2)[N:3]=1.[CH3:18][O:19][C:20]([CH:22]1[CH2:27][CH2:26][NH:25][CH2:24][CH2:23]1)=[O:21].CCN(CC)CC>CC(O)C.O>[CH3:17][O:16][C:7]1[CH:8]=[C:9]2[C:4](=[CH:5][CH:6]=1)[N:3]=[C:2]([N:25]1[CH2:26][CH2:27][CH:22]([C:20]([O:19][CH3:18])=[O:21])[CH2:23][CH2:24]1)[C:11]([C:12]([F:15])([F:14])[F:13])=[CH:10]2

参加物

6

反応物 3

HCID 8471TriethylamineHCID 424914Methyl isonipecotateHCID 866899362-Chloro-6-methoxy-3-(trifluoromethyl)quinoline2 回

生成物 1

HCID 66980108Methyl 1-(6-methoxy-3-(trifluoromethyl)quinolin-2-yl)piperidine-4-carboxylate収率 43%

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 3776Isopropanol溶媒

実験手順

To a solution of 2-chloro-6-methoxy-3-(trifluoromethyl)quinoline (1.00 g, 3.85 mmol) (see Intermediate 6, Step 8 for synthesis) in IPA (5 mL) was added methyl-4-piperidinecarboxylate (5.50 g, 38.5 mmol) and Et3N (1.17 g, 11.6 mmol). The mixture was heated to reflux for 48 hours. The mixture was diluted with water (100 mL) and extracted with DCM (100 mL×3), the combined organic layers were washed with brine (200 mL), dried over anhydrous Na2SO4, filtered and concentrated under reduced pressure to give the crude product, which was purified by column chromatography on silica gel (PE/EtOAc=15/1) to give the product (600 mg, yield 43%) as a solid.

後処理

  1. temperatureThe mixture was heated
  2. temperatureto reflux for 48 hours
  3. extractionextracted with DCM (100 mL×3)
  4. washthe combined organic layers were washed with brine (200 mL)
  5. dry with materialdried over anhydrous Na2SO4
  6. filtrationfiltered
  7. concentrationconcentrated under reduced pressure
  8. customto give the crude product, which
  9. customwas purified by column chromatography on silica gel (PE/EtOAc=15/1)

出典と根拠

ORDレコード
ord-91f426121a724ce7aa13b19804805233
出典データセット
uspto-grants-2016_09
特許番号
US09433618B2

関連ノート

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