関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Iodine | HCID 807 | — |
| 反応物 | Tetrahydrofuran | HCID 8028 | — |
| 反応物 | 2-Chloro-3-quinolinecarboxaldehyde | HCID 690958 | — |
| 反応物 | Azane;hydrate | HCID 12896473 | — |
| 生成物 | 2-Chloro-6-methoxyquinoline-3-carbonitrile | HCID 865612 | 38% |
反応手順
To a mixture of 2-chloroquinoline-3-carboxaldehyde (1.00 g, 4.50 mmol) in THF (30 mL) was added NH3.H2O (30 mL, 25%) and I2 (1.26 g, 4.90 mmol), the mixture was stirred at 20° C. for 8 hours. Aqueous workup with EtOAc extraction gave the crude product. Purification by silica gel column (PE/EtOAc=10/1 to 2/1) gave the product (370 mg, yield 38%) as a yellow solid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US09433618B2 |
|---|
| 出典データセット | uspto-grants-2016_09 |
|---|
| ORD ID | ord-22a2dad257f1404186296a5281e81c61 |
|---|
| 出典メモ | uspto-grants-2016_09 |
|---|
