Ammonia → 3-Cyanobenzamide

HRID 558317

反応式

HRID 558317 の反応式
[NH3:1].[C:2]([C:4]1[CH:5]=[C:6]([CH:10]=[CH:11][CH:12]=1)[C:7](Cl)=[O:8])#[N:3]>ClCCl>[C:2]([C:4]1[CH:5]=[C:6]([CH:10]=[CH:11][CH:12]=1)[C:7]([NH2:1])=[O:8])#[N:3]

参加物

4

反応物 2

HCID 222AmmoniaHCID 3084833-Cyanobenzoyl chloride

生成物 1

HCID 769743-Cyanobenzamide

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

0.88 Ammonia solution (30 ml) was slowly added to a solution of 3-cyanobenzoyl chloride (10 g, 60.3 mmol) in dichloromethane (100 ml) at 0° C. under nitrogen and the reaction was stirred for 20 minutes. The mixture was filtered and the solid was washed with water (50 ml) then diethylether (50 ml), azeotroped with toluene and dried in vacuo to provide the title compound (9 g) as a white solid.

後処理

  1. filtrationThe mixture was filtered
  2. washthe solid was washed with water (50 ml)
  3. customdiethylether (50 ml), azeotroped with toluene
  4. customdried in vacuo

出典と根拠

ORDレコード
ord-f90883a111af416d9a39944da9a1fccb
出典データセット
uspto-grants-2011_11
特許番号
US08063044B2

関連ノート

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