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Triethylamine → HCID 25071457、化合物
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Triethylamine | HCID 8471 | — |
| 反応物 | monoMethyl succinate | HCID 77487 | — |
| 反応物 | PyBOP | HCID 2724699 | — |
| 反応物 | 6-Amino-9-[3-(benzylamino)propyl]-2-butoxy-7,9-dihydro-8H-purin-8-one, dihydrochloride | HCID 131729285 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | HCID 25071457 | HCID 25071457 | — |
反応手順
PyBop (0.47 g) was added to a mixture of the product from example 1 step (viii) (0.25 g), Et3N (0.7 ml) and succinic acid monomethyl ester (0.16 g) in DMF (8 ml) and stirred at rt for 4 days. MeOH (10 ml) was added, the solvent evaporated under reduced pressure and the residue purified by RPHPLC, yield 46 mg.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08063051B2 |
| 出典データセット | uspto-grants-2011_11 |
| ORD ID | ord-01bd19a3c14b44299feb915fed82f286 |
| 出典メモ | uspto-grants-2011_11 |