化工社化工社 化学情報印刷レポート · 研究参考用
3-Chloropropionyl chloride → 3-chloro-N-(2-fluoro-4-hydroxyphenyl)propanamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 3-Chloropropionyl chloride | HCID 69364 | — |
| 反応物 | 4-Amino-3-fluorophenol | HCID 2735919 | — |
| 溶媒 | Acetone | HCID 180 | — |
| 生成物 | 3-chloro-N-(2-fluoro-4-hydroxyphenyl)propanamide | HCID 66980071 | 50.7% |
反応手順
4-Amino-3-fluorophenol (3.4 g) was mixed with 3-chloropropanoyl chloride (3.56 g) in acetone (60 mL) and heated at reflux over 3 hours. After aqueous work-up with EtOAc/water, the isolated organic layers were dried over Na2SO4 and concentrated in vacuo. The crude product was purified with silica gel chromatography to give the product (2.95 g) as a light brown solid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09433618B2 |
| 出典データセット | uspto-grants-2016_09 |
| ORD ID | ord-2e11691e25a74dbe9424770cd4a8d518 |
| 出典メモ | uspto-grants-2016_09 |