Hydrochloric Acid → 8-Fluoro-6-hydroxy-3,4-dihydroquinolin-2(1H)-one
反応式
Cl[CH2:2][CH2:3][C:4]([NH:6][C:7]1[CH:12]=[CH:11][C:10]([OH:13])=[CH:9][C:8]=1[F:14])=[O:5].[Al+3].[Cl-].[Cl-].[Cl-].Cl>>[F:14][C:8]1[CH:9]=[C:10]([OH:13])[CH:11]=[C:12]2[C:7]=1[NH:6][C:4](=[O:5])[CH2:3][CH2:2]2参加物
4
反応条件
- 温度
- 160 °C
実験手順
3-Chloro-N-(2-fluoro-4-hydroxyphenyl)propanamide (2.1 g) was mixed with anhydrous AlCl3 (7 g) and heated at 160° C. overnight. The resultant mixture was treated with 1N HCl and extracted with EtOAc. After isolation of the organic layer and removal of solvents under reduced pressure, the desired crude product (1.8 g) was collected as light brown solids.
後処理
- extractionextracted with EtOAc
- customAfter isolation of the organic layer and removal of solvents under reduced pressure
- customthe desired crude product (1.8 g) was collected as light brown solids
出典と根拠
- ORDレコード
- ord-751a4c22cc7c4afb9844290a8c529461
- 出典データセット
- uspto-grants-2016_09
- 特許番号
- US09433618B2
反応ノート
読み込み中…