化工社化工社 化学情報印刷レポート · 研究参考用
2-Amino-2-methyl-1,3-propanediol → 5-Bromo-6-chloro-N-(1,3-dihydroxy-2-methylpropan-2-yl)pyridine-3-sulfonamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2-Amino-2-methyl-1,3-propanediol | HCID 1531 | — |
| 反応物 | 5-Bromo-6-chloropyridine-3-sulfonyl chloride | HCID 2793626 | — |
| 生成物 | 5-Bromo-6-chloro-N-(1,3-dihydroxy-2-methylpropan-2-yl)pyridine-3-sulfonamide | HCID 86607992 | 83.4% |
反応手順
Prepared by general procedure III from 3-bromo-2-chloropyridine-5-sulphonylchloride (580 mg, 2 mmol) and 2-amino-2-methyl-1,3-propanediol (231 mg, 2 mmol) to give 5-Bromo-6-chloro-pyridine-3-sulfonic acid (2-hydroxy-1-hydroxymethyl-1-methyl-ethyl)-amide (600 mg, 83%) as a yellow solid. MS (ISN) 357 [(M−H)−], 359.0 [(M+2−H)−], 361.0 [(M+4−H)−].
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08063048B2 |
| 出典データセット | uspto-grants-2011_11 |
| ORD ID | ord-e1effc38f2bc4023a0214481c217e20c |
| 出典メモ | uspto-grants-2011_11 |